| County | County seat | Established | Origin |
| Abbeville County | Abbeville | 1785 | Ninety-Six District |
| Aiken County | Aiken | 1871 | Barnwell, Edgefield, Lexington, and Orangeburg |
| Allendale County | Allendale | 1919 | Barnwell and Hampton |
| Anderson County | Anderson | 1826 | Pendleton District |
| Bamberg County | Bamberg | 1897 | Barnwell |
| Barnwell County | Barnwell | 1798 | Orangeburg |
| Beaufort County | Beaufort | 1769 | 1769 Judicial District |
| Berkeley County | Moncks Corner | 1882 | Charleston |
| Calhoun County | St. Matthews | 1908 | Lexington and Orangeburg |
| Charleston County | Charleston | 1769 | 1769 Judicial District |
| Cherokee County | Gaffney | 1897 | Spartanburg, Union, and York |
| Chester County | Chester | 1785 | Camden District |
| Chesterfield County | Chesterfield | 1798 | Cheraws District |
| Clarendon County | Manning | 1855 | Sumter |
| Colleton County | Walterboro | 1800 | Charleston |
| Darlington County | Darlington | 1785 | Cheraws District |
| Dillon County | Dillon | 1910 | Marion |
| Dorchester County | St. George | 1868 | Berkeley and Colleton |
| Edgefield County | Edgefield | 1785 | Ninety-Six District |
| Fairfield County | Winnsboro | 1785 | Camden District |
| Florence County | Florence | 1888 | Clarendon, Darlington, Marion, and Williamsburg |
| Georgetown County | Georgetown | 1769 | 1769 Judicial District |
| Greenville County | Greenville | 1798 | Washington District |
| Greenwood County | Greenwood | 1897 | Abbeville and Edgefield |
| Hampton County | Hampton | 1787 | Beaufort |
| Horry County | Conway | 1801 | Georgetown |
| Jasper County | Ridgeland | 1912 | Beaufort and Hampton |
| Kershaw County | Camden | 1798 | Claremont, Fairfield, Lancaster, and Richland |
| Lancaster County | Lancaster | 1798 | Camden District |
| Laurens County | Laurens | 1785 | Ninety-Six District |
| Lee County | Bishopville | 1902 | Darlington, Kershaw, and Sumter |
| Lexington County | Lexington | 1804 | Orangeburg |
| Marion County | Marion | 1800 | Georgetown |
| Marlboro County | Bennettsville | 1798 | Cheraws District |
| McCormick County | McCormick | 1914 | Abbeville, Edgefield, and Greenwood |
| Newberry County | Newberry | 1785 | Ninety-Six District |
| Oconee County | Walhalla | 1868 | Pickens |
| Orangeburg County | Orangeburg | 1769 | 1769 Judicial District |
| Pickens County | Pickens | 1826 | Pendleton District |
| Richland County | Columbia | 1799 | Camden District |
| Saluda County | Saluda | 1896 | Edgefield |
| Spartanburg County | Spartanburg | 1785 | Ninety-Six District |
| Sumter County | Sumter | 1798 | Claremont, Clarendon, and Salem |
| Union County | Union | 1798 | Ninety-Six District |
| Williamsburg County | Kingstree | 1802 | Georgetown District |
| York County | York | 1798 | Camden District |
by John C. Rigdon | |||||
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